The Science Behind “Ozempic Teeth”: What’s Really Happening?

In our last post, we explored how patients on GLP-1 medications like Ozempic, Wegovy, and Mounjaro started using the phrase “Ozempic teeth” to describe new dental problems. But what’s actually going on behind the scenes?

Nausea and dry mouth are two common side effects of GLP-1 medications, and both can set the stage for dental problems if left unchecked.

Let’s break down the science of how these medications can indirectly impact your oral health.

1. Dry Mouth (Xerostomia): When Your Mouth’s Natural Shield Disappears

Think of saliva as your mouth’s built-in mouthwash. It rinses away bacteria, neutralizes acids, and keeps everything in balance.

But GLP-1 meds often reduce appetite and thirst, which means many patients end up dehydrated. Less water in the body = less saliva.

Without that protective rinse, your mouth becomes a sticky playground for bacteria, leading to:

• More plaque buildup

• Faster cavity formation

• Bad breath

• Higher risk of gum irritation

2. Nausea, Vomiting, and Acid Reflux: Stomach Acid Meets Tooth Enamel

Many GLP-1 users report nausea or even vomiting, side effects tied to how these drugs slow digestion. That slowdown can also trigger acid reflux.

Here’s why that matters: stomach acid is extremely corrosive. Each time it washes over your teeth, it erodes enamel, the protective shell around your teeth.

Imagine enamel like the armor on a knight. Once acid eats away at that armor, your teeth are left vulnerable to sensitivity, decay, and cracking.

3. Nutrient Deficiencies: Starving Your Smile

Because GLP-1 meds curb appetite so strongly, some patients unintentionally eat too little, or skip entire food groups. Over time, this can mean missing out on essential nutrients that keep teeth and gums healthy:

• Calcium & Vitamin D → build strong teeth and jawbone

• Vitamin C → supports gum health and healing

• B Vitamins → keep tissues healthy and fight inflammation

Think of it like building a house without enough bricks or mortar. Your mouth simply doesn’t have the raw materials it needs to stay strong.

4. Changes in Oral Habits: Feeling Sick Means Skipping Care

When you’re nauseous or exhausted, it’s easy to brush and floss less often. Some GLP-1 users admit they only gave their teeth a quick rinse on days they felt queasy.

That skipped routine gives plaque an open invitation to settle in, harden, and attack enamel and gums.

Why This Matters

To be clear: GLP-1 medications don’t directly “rot” teeth. Instead, their side effects can create the perfect storm for dental problems if you’re not careful.

• Less saliva = more bacteria

• More acid = weaker enamel

• Fewer nutrients = slower healing

• Less brushing = more plaque

Add them together, and you can see why some patients suddenly find themselves with “Ozempic teeth.”

What’s Next

The good news? Dentists are already offering solutions. From hydration strategies to special toothpastes, there are plenty of ways to protect your smile while staying on your medication.

👉 Stay tuned for the 3rd part in our series: : "Dentists Weigh In: Protecting Your Smile on GLP-1 Meds" to learn exactly what the experts recommend.